5F-MDMB-2201

5F-MDMB-2201, 5-Fluoro MDMB-PICA, 5F-MDMB-PICA (MDMB-5F-PICA) is a designer drug and synthetic cannabinoid. Products containing synthetic cannabinoids (e.g., JWH-018, UR-144, AKB48, etc.) laced on plant material are smoked for their psychoactive effects. Synthetic cannabinoids, a transition to new synthetic cannabinoids laced on plant material has been observed. 5F-MDMBPICA is a synthetic cannabinoid recently encountered on the designer drug market and has been found laced on plant material and marketed under the guise of herbal incense products.

5F-MDMB-PICA Chemistry:

The chemical structure for 5F-MDMB-PICA1 is shown
below

5F-MDMB-PICA is classified as an indole. 5F-MDMBPICA is based on an indole core structure, where the 1- and 3-positions of the indole ring system are substituted.

The 1-position of 5F-MDMB-PICA is substituted with a linear five
carbon chain terminated with a fluorine (F) atom. The 3- position is substituted with an amide linker, and the nitrogen (N) atom of this linker is further substituted with a 1-methoxy3,3-dimethyl-1-oxobutan-2-yl group.

5F-MDMB-2201 Pharmacology:

Data from preclinical studies show that 5F-MDMB- PICA binds to and acts as an agonist at the CB1 receptor. In drug discrimination studies in rats, 5F-MDMB-PICA generalized to Δ9-THC, i.e. produced subjective effects similar to those of Δ9-THC.

There are no published studies on the safety of 5FMDMB-PICA for human use.