Description
JHW-018
JHW-018 cannabinoid also known as (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2.
It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use as synthetic cannabinoid products that, in some countries, are sold legally as “incense blends” Methyl Salicylate
JHW-018 Pharmacology
JWH-018 is a full agonist of both the CB1 and CB2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2.
JWH-018 has an EC of 102 nM for human CB1 receptors, and 133 nM for human CB2 receptors.
JWH-018 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity.
Technical Data for JWH 018
| M. Wt | 341.45 |
| Formula | C24H23NO |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 209414-07-3 |
| PubChem ID | 10382701 |
| InChI Key | JDNLPKCAXICMBW-UHFFFAOYSA-N |
| Smiles | O=C(C3=CN(CCCCC)C4=C3C=CC=C4)C1=CC=CC2=C1C=CC=C2 |
The technical data provided above is for guidance only. Pyrazolam Powder
JHW-018 Cannabinoid Synthesis
JWH 018 is an analytical reference material categorized as a synthetic cannabinoid.1 It has been found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 018 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.
WARNING This product is not for human or veterinary use.
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