N-Formylamphetamine is a precursor in the synthesis of amphetamine and a potential impurity found in seized amphetamine samples. It is a metabolite of N-cyanomethylmethamphetamine and N-formylmethamphetamine . This product is intended for research and forensic applications.
Formetorex (INN), also known as formetamide or N-formylamphetamine, is a substituted amphetamine described as an anorectic which does not appear to have ever been marketed.
Formetorex is also an intermediate in the production of amphetamine by the “Leuckart reaction.” It is also commonly found as an impurity in clandestine labs where this synthesis method is used. Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines.
Amphetamine – Leuckart reaction
The synthesis involves a non-metal reduction that is typically carried out in three steps. For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium formate, is heated until a condensation reaction results in the intermediate product, formetamide. In the second step, formetamide is hydrolysed using hydrochloric acid, and the reaction mixture is then basified, isolated, and steam distilled to produce the free base. The final step, the product is dissolved in an organic solvent and precipitated as the sulphate salt of amphetamine by adding sulfuric acid.
