Diethyl(phenylacetyl)malonate can be used to synthesize methylanhydroacetonebenzil. While sym-dimethylanhydroacetonebenzil when treated with acidic dehydrating agents forms a bimol.
Diethyl(phenylacetyl)malonate Properties
| Boiling point | 120 °C(Press: 0.01 Torr) |
|---|---|
| Density | 1.148±0.06 g/cm3(Predicted) |
| pka | 8.76±0.59(Predicted) |
| InChI | InChI=1S/C15H18O5/c1-3-19-14(17)13(15(18)20-4-2)12(16)10-11-8-6-5-7-9-11/h5-9,13H,3-4,10H2,1-2H3 |
| InChIKey | ZASPDQDIPTZTQQ-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(C(CC1=CC=CC=C1)=O)C(OCC)=O |
Diethyl(phenylacetyl)malonate Chemical
Physical properties
Diethyl(phenylacetyl)malonate has a boiling point of 120 °C. Its density is predicted to be 1.148±0.06 g/cm3.
Uses
Organic synthesis intermediates.
Preparation
The anhydrous ethanol co-vaporized with diethyl phthalate and sodium metal is added dropwise to the mixture of diethyl malonate, carbon tetrachloride and magnesium, heated to start the reaction, and the temperature is controlled to smooth the reaction. Then add anhydrous diethyl ether, heat for 1h, add the diethyl ether solution of phenylacetyl chloride (add slowly, not to make the reaction too intense). After the reaction is completed, cool and add water, separate the oil layer, and evaporate the diethyl ether under reduced pressure to obtain diethyl(phenylacetyl)malonate.
Diethyl(phenylacetyl)malonate Synthesis
Synthesis of Diethyl(phenylacetyl)malonate from Ethanol and 1,3-Dioxane-4,6-dione, 2,2-dimethyl-5-(2-phenylacetyl)-
Diethyl(phenylacetyl)malonate Preparation Products And Raw materials
Raw materials
Diethyl phthalate
Carbon tetrachloride
Diethyl ether
Phenylacetyl chloride
Malonic acid
Diethyl(phenylacetyl)malonate Details
CAS No: 20320-59-6
Chemical Name: Diethyl(phenylacetyl)malonate
Synonyms: Diethyl(phenylacetyl)malonate, Cas 20320-59-6, new p, Propanedioic;20320 59 6, Phenylacetylmalonsaeurediethylester, diethyl 2-(2-phenylacetyl)propanedioate, diethyl 2-(2-phenylacetyl)propanedioate, New BMK Oil, BMK Oil/powder, bmk Lliquid oil,
CBNumber: CB61075043
Molecular Formula: C15H18O5
Molecular Weight: 278.3
MDL Number: MFCD28989869