Chlorodiazepam

Chlorodiazepam may be refered to Diclazepam, or 2′-Chlorodiazepam, a benzodiazepine designer drug with typical sedative and anxiolytic effects and functional analog of diazepam.

Chlorodiazepam Synonyms

• 2-chlorodiazepam
• 2H-1,4-benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-methyl-
• diclazepam
• Ro 5-3448

Diclazepam Metabolism

Metabolism of this compound has been assessed, revealing diclazepam has an approximate elimination half-life of 42 hours and undergoes N-demethylation to delorazepam, which can be detected in urine for 6 days following administration of the parent compound.

Other metabolites detected were lorazepam and lormetazepam which were detectable in urine for 19 and 11 days, respectively, indicating hydroxylation by cytochrome P450 enzymes occurring concurrently with N-demethylation.