Mandrax (Quaalude) Methaqualone, formerly sold under the brand name Quaalude and Mandrax, is a sedative and hypnotic medication. It is a member of the quinazolinone class. The sedative–hypnotic activity of methaqualone was first noted in the 1950s. In 1962, Mandrax (Methaqualone) 300mg methaqualone was patented in the US by Wallace and Tiernan.Quaaludes (methaqualone) is a synthetic, barbiturate-like, central nervous system depressant and a popular recreational drug in the U.S. from the 1960s until the 1980s, when its use was made illegal by the Drug Enforcement Agency (DEA). The active ingredient, methaqualone, is an anxiolytic (lowers anxiety) and a sedative-hypnotic drug that leads to a state of drowsiness. These drugs, imprinted with the number “714” on the tablet, were initially introduced as a safe barbiturate substitute to help induce sleep but were later shown to have addiction and withdrawal symptoms similar to other prescription barbiturates. Quaaludes are rarely encountered on the streets in the U.S. today but are occasionally confiscated coming across the border.
When it was a legal medication, methaqualone was available in tablet and capsule form and came in different strengths.
A commonly prescribed dose was 300 mg. Up to 600 mg was used for strong sedation.
Tolerance develops rapidly and some users may take up to 2000 mg daily to achieve the same effects.
The onset of action is approximately 30 minutes after taking Quaaludes and duration of action is between 5 to 8 hours.